Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes.

@article{Hauser2006MelaninCA,
  title={Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes.},
  author={Jennifer E Hauser and Ana Luisa Kadekaro and Renny J Kavanagh and Kazumasa Wakamatsu and Silva Terzieva and Sandy J Schwemberger and George E Babcock and M. J. Balakrishna Rao and Shosuke Ito and Zalfa A Abdel-Malek},
  journal={Pigment cell research},
  year={2006},
  volume={19 4},
  pages={303-14}
}
Malignant transformation of melanocytes leads to melanoma, the most fatal form of skin cancer. Ultraviolet radiation (UVR)-induced DNA photoproducts play an important role in melanomagenesis. Cutaneous melanin content represents a major photoprotective mechanism against UVR-induced DNA damage, and generally correlates inversely with the risk of skin cancer, including melanoma. Melanoma risk is also determined by susceptibility genes, one of which is the melanocortin 1 receptor (MC1R) gene… CONTINUE READING

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