Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.

  title={Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.},
  author={William Thomas Gibson and Pavlos Pissios and Daniel J Trombly and Jian'an Luan and Julia Keogh and Nicholas J Wareham and Eleftheria Maratos-Flier and Stephen O'Rahilly and I Sadaf Farooqi},
  journal={Obesity research},
  volume={12 5},
Melanin-concentrating hormone (MCH), a neuropeptide highly expressed in the lateral hypothalamus, has an important role in the regulation of energy balance and body weight in rodents. We examined whether mutations in the two known MCH receptors might be associated with obesity-related phenotypes in humans. Among 106 subjects with severe early onset obesity and a history of hyperphagia, we found two missense variants in MCHR1: Y181H and R248Q. Neither of these was found in 192 normal weight… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…