Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype.

  title={Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype.},
  author={Gabriella Segal-Lieberman and Richard L Bradley and Efi G Kokkotou and Michael Carlson and Daniel J Trombly and Xiaomei Wang and Sarah Bates and Martin G Myers and Jeffrey S. Flier and Eleftheria Maratos-Flier},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 17},
Energy homeostasis is regulated by a complex network involving peripheral and central signals that determine food intake and energy expenditure. Melanin-concentrating hormone (MCH) plays an essential role in this process. Animals treated with MCH develop hyperphagia and obesity. Ablation of the prepro-MCH gene leads to a lean phenotype, as does ablation of the rodent MCH receptor, MCHR-1. MCH is overexpressed in the leptin-deficient ob/ob mouse, and we hypothesized that ablation of MCH in this… CONTINUE READING


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