Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice.

@article{Ito2009MelaninconcentratingH1,
  title={Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice.},
  author={Masahiko Ito and Akane Ishihara and Akira Gomori and Shinichiro Egashira and Hiroko Matsushita and Satoshi Mashiko and Junko It{\^o} and Makoto Ito and Kazuho Nakase and Yuji Haga and Hisashi Iwaasa and Takao K Suzuki and Norikazu Ohtake and Minoru Moriya and Nagaaki Sato and Douglas J Macneil and Norihiro Takenaga and Shigeru Tokita and Akio Kanatani},
  journal={European journal of pharmacology},
  year={2009},
  volume={624 1-3},
  pages={77-83}
}
Melanin-concentrating hormone (MCH), which is a neuropeptide expressed in the hypothalamus of the brain, is involved in regulating feeding behavior and energy homeostasis via the MCH(1) receptor in rodents. It is widely considered that MCH(1) receptor antagonists are worthy of development for medical treatment of obesity. Here we report on the development of an ex vivo receptor occupancy assay using a new radiolabeled MCH(1) receptor antagonist, [(35)S]-compound D. An MCH(1) receptor antagonist… CONTINUE READING
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A neuropeptide YY5 antagonist selectively ameliorates body weight gain and associated parameters in dietinduced obese mice

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