Melanin-concentrating hormone-1 receptor antagonism decreases feeding by reducing meal size.

@article{Kowalski2004MelaninconcentratingHR,
  title={Melanin-concentrating hormone-1 receptor antagonism decreases feeding by reducing meal size.},
  author={Timothy J. Kowalski and Constance Farley and Mary E. Cohen-Williams and Geoffrey B. Varty and Brian D Spar},
  journal={European journal of pharmacology},
  year={2004},
  volume={497 1},
  pages={41-7}
}
Prior work has demonstrated that melanin-concentrating hormone-1 (MCH-1) receptor antagonism decreases food intake and body weight in obese rodents. The purpose of this study was to determine if the MCH-1 receptor antagonist-mediated hypophagia was due a decrease in meal size, meal frequency, or both. We performed a meal pattern analysis in free-feeding hyperphagic diet-induced obese (DIO) rats treated with 1, 3 or 10 mg/kg p.o. of the MCH-1 receptor antagonist T-226296 (a (-)enantiomer of N-[6… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…