Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus.

  title={Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus.},
  author={David S. Ludwig and Kathleen G. Mountjoy and Jeffrey B. Tatro and Jennifer A Gillette and Robert C. Frederich and Jeffrey S. Flier and Eleftheria Maratos-Flier},
  journal={The American journal of physiology},
  volume={274 4 Pt 1},
Melanin-concentrating hormone (MCH) and alpha-melanocyte-stimulating hormone (alpha-MSH) demonstrate opposite actions on skin coloration in teleost fish. Both peptides are present in the mammalian brain, although their specific physiological roles remain largely unknown. In this study, we examined the interactions between MCH and alpha-MSH after intracerebroventricular administration in rats. MCH increased food intake in a dose-dependent manner and lowered plasma glucocorticoid levels through a… CONTINUE READING
76 Citations
49 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 76 extracted citations


Publications referenced by this paper.
Showing 1-10 of 49 references

MCH: A MELANOCORTIN ANTAGONIST by on M ay 7, 2017 D ow nladed fom

  • D. Huszar, C. A. Lynch, +9 authors P.L.A. Campfield
  • Cell 88:
  • 1997
1 Excerpt

Targeted disruption of the melanocortin4 receptor results in obesity in mice

  • D. Jezova, V. Bartanusz, I. Westergren, B. B. Johansson, J. Rivier, W. Vale
  • Cell
  • 1997

Similar Papers

Loading similar papers…