Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus.

@article{Ludwig1998MelaninconcentratingHA,
  title={Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus.},
  author={David S. Ludwig and Kathleen G. Mountjoy and Jeffrey B. Tatro and Jennifer A Gillette and Robert C. Frederich and Jeffrey S. Flier and Eleftheria Maratos-Flier},
  journal={The American journal of physiology},
  year={1998},
  volume={274 4 Pt 1},
  pages={E627-33}
}
Melanin-concentrating hormone (MCH) and alpha-melanocyte-stimulating hormone (alpha-MSH) demonstrate opposite actions on skin coloration in teleost fish. Both peptides are present in the mammalian brain, although their specific physiological roles remain largely unknown. In this study, we examined the interactions between MCH and alpha-MSH after intracerebroventricular administration in rats. MCH increased food intake in a dose-dependent manner and lowered plasma glucocorticoid levels through a… CONTINUE READING
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