Melanin and pyomelanin in Aspergillus fumigatus: from its genetics to host interaction

@article{PerezCuesta2019MelaninAP,
  title={Melanin and pyomelanin in Aspergillus fumigatus: from its genetics to host interaction},
  author={U. Perez-Cuesta and L. Aparicio-Fernandez and X. Guruceaga and L. Martin-Souto and A. Abad-Diaz-de-Cerio and A. Antoran and I. Buldain and F. Hernando and A. Ramirez-Garcia and A. Rementeria},
  journal={International Microbiology},
  year={2019},
  pages={1-9}
}
Aspergillus fumigatus is a worldwide-distributed saprophytic fungus and the major cause of invasive aspergillosis. This fungus can produce two types of melanin—dihydroxynaphthalene melanin (DHN-melanin) and pyomelanin. These pigments are considered important resistance mechanisms to stress, as well as virulence factors. The aim of this review is to present the current knowledge of the genetic basis and metabolic pathways of melanin production, their activation, function, and interaction with… Expand
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