Melanin Aggregation and Polymerization: Possible Implications in Age-Related Macular Degeneration

@article{Sarangarajan2005MelaninAA,
  title={Melanin Aggregation and Polymerization: Possible Implications in Age-Related Macular Degeneration},
  author={Rangaprasad Sarangarajan and Shireesh P. Apte},
  journal={Ophthalmic Research},
  year={2005},
  volume={37},
  pages={136 - 141}
}
The state of aggregation of the polymer melanin may determine its propensity to act either as an antioxidant or as a pro-oxidant. Age-related alterations in its state of aggregation are suggested to alter the degree of polymerization so as to confer increased pro-oxidant propensity to the melanin polymer. Degradative processes in/of melanosomes and lysosomes in the retinal pigment epithelium (RPE) appear to be intimately connected so that they may involve exchange of contents between these two… Expand
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