Melanin Aggregation and Polymerization: Possible Implications in Age-Related Macular Degeneration

  title={Melanin Aggregation and Polymerization: Possible Implications in Age-Related Macular Degeneration},
  author={R. Sarangarajan and S. Apte},
  journal={Ophthalmic Research},
  pages={136 - 141}
  • R. Sarangarajan, S. Apte
  • Published 2005
  • Biology, Medicine
  • Ophthalmic Research
  • The state of aggregation of the polymer melanin may determine its propensity to act either as an antioxidant or as a pro-oxidant. Age-related alterations in its state of aggregation are suggested to alter the degree of polymerization so as to confer increased pro-oxidant propensity to the melanin polymer. Degradative processes in/of melanosomes and lysosomes in the retinal pigment epithelium (RPE) appear to be intimately connected so that they may involve exchange of contents between these two… CONTINUE READING
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