Melanesian Blond Hair Is Caused by an Amino Acid Change in TYRP1

@article{Kenny2012MelanesianBH,
  title={Melanesian Blond Hair Is Caused by an Amino Acid Change in TYRP1},
  author={E. Kenny and N. Timpson and M. Sikora and Muh-Ching Yee and Andr{\'e}s Moreno-Estrada and C. Eng and Shane A Huntsman and E. Burchard and M. Stoneking and C. Bustamante and S. Myles},
  journal={Science},
  year={2012},
  volume={336},
  pages={554 - 554}
}
  • E. Kenny, N. Timpson, +8 authors S. Myles
  • Published 2012
  • Biology, Medicine
  • Science
  • Naturally blond hair in Solomon Islanders maps to a missense mutation in a gene associated with pigmentation. Naturally blond hair is rare in humans and found almost exclusively in Europe and Oceania. Here, we identify an arginine-to-cysteine change at a highly conserved residue in tyrosinase-related protein 1 (TYRP1) as a major determinant of blond hair in Solomon Islanders. This missense mutation is predicted to affect catalytic activity of TYRP1 and causes blond hair through a recessive mode… CONTINUE READING
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