Melamine induces human renal proximal tubular cell injury via transforming growth factor-β and oxidative stress.

@article{Hsieh2012MelamineIH,
  title={Melamine induces human renal proximal tubular cell injury via transforming growth factor-β and oxidative stress.},
  author={T. Hsieh and P. Hsieh and Yi-Hong Tsai and C. Wu and C. Liu and Ming-Yen Lin and M. Wu},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2012},
  volume={130 1},
  pages={
          17-32
        }
}
  • T. Hsieh, P. Hsieh, +4 authors M. Wu
  • Published 2012
  • Chemistry, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
Although several reports have failed to observe adverse subchronic renal effects following relatively high melamine exposure, the safety of low and continuous melamine exposure is still debatable. Recent studies suggest that long-term, low-dose melamine exposure is associated with an increased risk of urolithiasis, which has been linked to chronic kidney disease (CKD). CKD is a consequence of nephron loss and is associated with the interaction of inflammation, oxidative stress, and transforming… Expand
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