Melamine-Induced Renal Toxicity Is Mediated by the Gut Microbiota

@article{Zheng2013MelamineInducedRT,
  title={Melamine-Induced Renal Toxicity Is Mediated by the Gut Microbiota},
  author={Xiaojiao Zheng and Aihua Zhao and Guoxiang Xie and Yi Chi and Linjing Zhao and Houkai Li and Congrong Wang and Yuqian Bao and Weiping Jia and Michael F. Luther and Ming-ming Su and Jeremy K. Nicholson and Wei Jia},
  journal={Science Translational Medicine},
  year={2013},
  volume={5},
  pages={172ra22 - 172ra22}
}
Melamine is converted to cyanuric acid by the gut microbe Klebsiella, leading to melamine-cyanurate-urate coprecipitation that is associated with nephrotoxicity. An Unwitting Microbial Culprit in Melamine Toxicity? A tragic incident in China in 2008 involving the deliberate and illicit supplementation of milk with melamine resulted in the deaths of children from renal failure and highlighted the toxicity of this compound. In a new study, Zheng et al. study the toxicity of melamine in rats and… Expand
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DMD065698 1505..1521
Information on the intestinal microbiota has increased exponentially this century because of technical advancements in genomics and metabolomics. Although information on the synthesis of bile acidsExpand
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