Mek1 phosphorylation site mutants activate Raf-1 in NIH 3T3 cells.

  title={Mek1 phosphorylation site mutants activate Raf-1 in NIH 3T3 cells.},
  author={Alessandro A Alessandrini and H. -G. Greulich and Wei Huang and Raymond Leo Erikson},
  journal={The Journal of biological chemistry},
  volume={271 49},
MAP (mitogen-activated protein) kinases are activated by a family of dual specificity kinases called Meks (MAP kinase/Erk kinase). Mek1 can be activated by Raf by phosphorylation on serine 218 and serine 222. Mutation of these sites to acidic residues leads to constitutively active Mek1 in some cases. When fibroblast lines were infected with high titer retroviral stocks carrying these Mek1 genes, the resultant transformation and morphological changes correlated with the kinase activity of the… CONTINUE READING

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