Meis2 is essential for cranial and cardiac neural crest development

  title={Meis2 is essential for cranial and cardiac neural crest development},
  author={Ondřej Machoň and Jan Ma{\vs}ek and Olga Machoňov{\'a} and Stefan Krauss and Zbyněk Kozm{\'i}k},
  booktitle={BMC Developmental Biology},
TALE-class homeodomain transcription factors Meis and Pbx play important roles in formation of the embryonic brain, eye, heart, cartilage or hematopoiesis. Loss-of-function studies of Pbx1, 2 and 3 and Meis1 documented specific functions in embryogenesis, however, functional studies of Meis2 in mouse are still missing. We have generated a conditional allele of Meis2 in mice and shown that systemic inactivation of the Meis2 gene results in lethality by the embryonic day 14 that is accompanied… CONTINUE READING
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