Meiotic spindle, spindle checkpoint and embryonic aneuploidy.

@article{Wang2006MeioticSS,
  title={Meiotic spindle, spindle checkpoint and embryonic aneuploidy.},
  author={Wei Wang and Qing-Yuan Sun},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2006},
  volume={11},
  pages={620-36}
}
In mitosis, a spindle checkpoint plays important roles at the metaphase-anaphase transition to ensure the formation of a bipolar spindle, the completion of connecting chromosomes to microtubules and the alignment of all chromosomes at the spindle equator before initiation of anaphase. Components of the spindle checkpoint were first identified through genetic screens in budding yeast and some checkpoint proteins later were found in a wide range of cells from yeast to human. However, the presence… CONTINUE READING

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Here we review recent progress on checkpoint studies in both mitosis and meiosis , toward an understanding of the checkpoint signal transduction pathway and its role in preventing chromosome abnormalities during meiosis .
Here we review recent progress on checkpoint studies in both mitosis and meiosis , toward an understanding of the checkpoint signal transduction pathway and its role in preventing chromosome abnormalities during meiosis .
MeiosisNo subtypeMitosis
Here we review recent progress on checkpoint studies in both mitosis and meiosis , toward an understanding of the checkpoint signal transduction pathway and its role in preventing chromosome abnormalities during meiosis .
Here we review recent progress on checkpoint studies in both mitosis and meiosis , toward an understanding of the checkpoint signal transduction pathway and its role in preventing chromosome abnormalities during meiosis .
MitosisNo subtypeMeiosis
Here we review recent progress on checkpoint studies in both mitosis and meiosis , toward an understanding of the checkpoint signal transduction pathway and its role in preventing chromosome abnormalities during meiosis .
Here we review recent progress on checkpoint studies in both mitosis and meiosis , toward an understanding of the checkpoint signal transduction pathway and its role in preventing chromosome abnormalities during meiosis .
In mitosis , a spindle checkpoint plays important roles at the metaphase - anaphase transition to ensure the formation of a bipolar spindle , the completion of connecting chromosomes to microtubules and the alignment of all chromosomes at the spindle equator before initiation of anaphase .
MitosisNo subtypeAnaphase
In mitosis , a spindle checkpoint plays important roles at the metaphase - anaphase transition to ensure the formation of a bipolar spindle , the completion of connecting chromosomes to microtubules and the alignment of all chromosomes at the spindle equator before initiation of anaphase .
AnaphaseNo subtypeMitosis
In mitosis , a spindle checkpoint plays important roles at the metaphase - anaphase transition to ensure the formation of a bipolar spindle , the completion of connecting chromosomes to microtubules and the alignment of all chromosomes at the spindle equator before initiation of anaphase .
However , the presence and function of the spindle checkpoint in mammalian meiosis , especially female meiosis , have long been disputed but evidence is now accumulating to support the existence .
AnaphaseNo subtypeMitosis
In mitosis , a spindle checkpoint plays important roles at the metaphase - anaphase transition to ensure the formation of a bipolar spindle , the completion of connecting chromosomes to microtubules and the alignment of all chromosomes at the spindle equator before initiation of anaphase .
Components of the spindle checkpoint were first identified through genetic screens in budding yeast and some checkpoint proteins later were found in a wide range of cells from yeast to human .
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