Meiotic recombination provokes functional activation of the p53 regulatory network.

@article{Lu2010MeioticRP,
  title={Meiotic recombination provokes functional activation of the p53 regulatory network.},
  author={Wan-Jin Lu and Joseph A Chapo and Ignasi Roig and John M. Abrams},
  journal={Science},
  year={2010},
  volume={328 5983},
  pages={1278-81}
}
The evolutionary appearance of p53 protein probably preceded its role in tumor suppression, suggesting that there may be unappreciated functions for this protein. Using genetic reporters as proxies to follow in vivo activation of the p53 network in Drosophila, we discovered that the process of meiotic recombination instigates programmed activation of p53 in the germ line. Specifically, double-stranded breaks in DNA generated by the topoisomerase Spo11 provoked functional p53 activity, which was… CONTINUE READING
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