Meiotic double-strand breaks occur once per pair of (sister) chromatids and, via Mec1/ATR and Tel1/ATM, once per quartet of chromatids.

@article{Zhang2011MeioticDB,
  title={Meiotic double-strand breaks occur once per pair of (sister) chromatids and, via Mec1/ATR and Tel1/ATM, once per quartet of chromatids.},
  author={Liangran Zhang and Keun Pil Kim and Nancy E. Kleckner and Aurora Storlazzi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 50},
  pages={20036-41}
}
Meiotic recombination initiates via programmed double-strand breaks (DSBs). We investigate whether, at a given initiation site, DSBs occur independently among the four available chromatids. For a single DSB "hot spot", the proportions of nuclei exhibiting zero, one, or two (or more) observable events were defined by tetrad analysis and compared with those predicted by different DSB distribution scenarios. Wild-type patterns are incompatible with independent distribution of DSBs among the four… CONTINUE READING

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ATM controls meiotic doublestrandbreak formation

  • J Lange
  • Nature
  • 2011

Meiotic chromosome dynamics. Genome Organization and Function in the Cell Nucleus, eds Karsten R (WILEY-VCH Verlag GmbH

  • N Kleckner, L Zhang, B Weiner, D Zickler
  • 2011

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