Meiotic arrest and aneuploidy in MLH3-deficient mice

  title={Meiotic arrest and aneuploidy in MLH3-deficient mice},
  author={Steven Lipkin and Peter B. Moens and Victoria J Wang and Michelle L. Lenzi and Dakshine Shanmugarajah and Abigail Gilgeous and James W. Thomas and Jun Cheng and Jeffrey W. Touchman and Eric D. Green and Pam Schwartzberg and Francis S. Collins and Paula E. Cohen},
  journal={Nature Genetics},
MutL homolog 3 (Mlh3) is a member of a family of proteins conserved during evolution and having dual roles in DNA mismatch repair and meiosis. The pathway in eukaryotes consists of the DNA-binding components, which are the homologs of the bacterial MutS protein (MSH 2–6), and the MutL homologs, which bind to the MutS homologs and are essential for the repair process. Three of the six homologs of MutS that function in these processes, Msh2, Msh3 and Msh6, are involved in the mismatch repair of… CONTINUE READING
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The time course and localization of recombination-related proteins at meiosis in the mouse conform to models that can resolve the early DNA-DNA interactions without reciprocal recombination

  • Moens, P.B
  • J. Cell Sci
  • 2002

Strategies for the systematic sequencing of complex genomes

  • E. D. Green
  • Nature Rev. Genet
  • 2001

a monomeric GHL ATPase

  • A. Guarne, M. S. Junop, Yang, W. Structure, function of the N-terminal 40 kDa fragment of human PMS2
  • EMBO J. 20, 5521–5531
  • 2001

Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes

  • Ellsworth, R.E
  • Proc. Natl Acad. Sci. USA
  • 2000

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