Meiotic arrest and aneuploidy in MLH3-deficient mice

@article{Lipkin2002MeioticAA,
  title={Meiotic arrest and aneuploidy in MLH3-deficient mice},
  author={Steven Lipkin and Peter B. Moens and Victoria J Wang and Michelle L. Lenzi and Dakshine Shanmugarajah and Abigail Gilgeous and James W. Thomas and Jun Cheng and Jeffrey W. Touchman and Eric D. Green and Pam Schwartzberg and Francis S. Collins and Paula E. Cohen},
  journal={Nature Genetics},
  year={2002},
  volume={31},
  pages={385-390}
}
MutL homolog 3 (Mlh3) is a member of a family of proteins conserved during evolution and having dual roles in DNA mismatch repair and meiosis. The pathway in eukaryotes consists of the DNA-binding components, which are the homologs of the bacterial MutS protein (MSH 2–6), and the MutL homologs, which bind to the MutS homologs and are essential for the repair process. Three of the six homologs of MutS that function in these processes, Msh2, Msh3 and Msh6, are involved in the mismatch repair of… CONTINUE READING
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