Meiotic and mitotic nondisjunction: lessons from preimplantation genetic diagnosis.

@article{Kuliev2004MeioticAM,
  title={Meiotic and mitotic nondisjunction: lessons from preimplantation genetic diagnosis.},
  author={Anver Kuliev and Yury Verlinsky},
  journal={Human reproduction update},
  year={2004},
  volume={10 5},
  pages={401-7}
}
Direct testing of the outcome of the first and second meiotic divisions has become possible with the introduction of preimplantation genetic diagnosis (PGD) for aneuploidies. Testing of oocytes by fluorescent in situ hybridization (FISH) analysis of the first and second polar bodies showed that more than half of oocytes from the IVF patients aged 35 years and older had chromosomal abnormalities, which originated from errors in meiosis I or meiosis II, or both: 41.9% of oocytes were aneuploid… CONTINUE READING

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References

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Showing 1-10 of 44 references

Aneuploidy rescue after female meiosis I and follow up analysis of its outcome in resulting preimplantation embryos

  • A Kuliev, J Cieslak, Z Zlatopolsky, Y Ilkevitch, I Kirilova, Y Verlinsky
  • Am J Hum Genet
  • 2003
Highly Influential
5 Excerpts

Origin of aneuploidies in preimplantation embryos

  • A Kuliev, J Cieslak, Z Zlatopolsky, Y Ilkevitch, I Kirilova, Y Verlinsky
  • Fifth International Symposium on Preimplantation…
  • 2003
Highly Influential
5 Excerpts

Pregnancies following preconception diagnosis of common aneuploidies by FISH

  • Y Verlinsky, J Cieslak, M Freidin
  • Hum Reprod
  • 1995
Highly Influential
4 Excerpts

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