Meiotic Silencing by Unpaired DNA

@article{Shiu2001MeioticSB,
  title={Meiotic Silencing by Unpaired DNA},
  author={Patrick K. T. Shiu and Namboori B. Raju and D. Zickler and Robert L. Metzenberg},
  journal={Cell},
  year={2001},
  volume={107},
  pages={905-916}
}
The silencing of gene expression by segments of DNA present in excess of the normal number is called cosuppression in plants and quelling in fungi. We describe a related process, meiotic silencing by unpaired DNA (MSUD). DNA unpaired in meiosis causes silencing of all DNA homologous to it, including genes that are themselves paired. A semidominant Neurospora mutant, Sad-1, fails to perform MSUD. Sad-1 suppresses the sexual phenotypes of many ascus-dominant mutants. MSUD may provide insights… CONTINUE READING
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Perspective : transposableBasic logical alignment search tool

  • M. G. Kidwell, D. R. Lisch
  • J . Mol . Biol . evolution
  • 2001
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