Meiotic Regulation of TPX2 Protein Levels Governs Cell Cycle Progression in Mouse Oocytes

@article{Brunet2008MeioticRO,
  title={Meiotic Regulation of TPX2 Protein Levels Governs Cell Cycle Progression in Mouse Oocytes},
  author={St{\'e}phane Brunet and Julien Dumont and Karen Wing-Man Lee and Kazuhisa Kinoshita and Pascale Hikal and Oliver J Gruss and B. Maro and Marie-H{\'e}l{\`e}ne Verlhac},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={259 - 269}
}
Formation of female gametes requires acentriolar spindle assembly during meiosis. Mitotic spindles organize from centrosomes and via local activation of the RanGTPase on chromosomes. Vertebrate oocytes present a RanGTP gradient centred on chromatin at all stages of meiotic maturation. However, this gradient is dispensable for assembly of the first meiotic spindle. To understand this meiosis I peculiarity, we studied TPX2, a Ran target, in mouse oocytes. Strikingly, TPX2 activity is controlled… CONTINUE READING
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