Meiotic Recombination in C. elegans Initiates by a Conserved Mechanism and Is Dispensable for Homologous Chromosome Synapsis
@article{Dernburg1998MeioticRI, title={Meiotic Recombination in C. elegans Initiates by a Conserved Mechanism and Is Dispensable for Homologous Chromosome Synapsis}, author={Abby F. Dernburg and K. Mcdonald and Gary L. Moulder and Robert J. Barstead and Michael E. Dresser and Anne M. Villeneuve}, journal={Cell}, year={1998}, volume={94}, pages={387-398} }
742 Citations
The Arabidopsis thaliana MND1 homologue plays a key role in meiotic homologous pairing, synapsis and recombination
- BiologyJournal of Cell Science
- 2006
It is demonstrated that the AtMND1 protein interacts with AHP2, the Arabidopsis protein closely related to budding yeast Hop2, and plays a key role in homologous synapsis and in DSB repair during meiotic recombination.
Chromosome pairing and meiotic recombination in Neurospora crassa spo11 mutants
- BiologyCurrent Genetics
- 2006
It is reported here that mutation of Neurosporaspo11 disrupts meiosis, abolishing synapsis of homologous chromosomes during pachynema and resulting in ascospores that are frequently aneuploid and rarely viable.
Mechanism and control of meiotic recombination initiation.
- BiologyCurrent topics in developmental biology
- 2001
Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2.
- BiologyGenes & development
- 2001
It is proposed that chk-2 functions during premeiotic S phase to enable chromosomes to become competent for subsequent meiotic prophase events and/or to coordinate replication with entry into prophase.
C. elegans DSB-3 Reveals Conservation and Divergence among Protein Complexes Promoting Meiotic Double-Strand Breaks
- BiologybioRxiv
- 2021
A cohort of proteins comprising a complex required for meiotic DSB formation in Caenorhabditis elegans is investigated, providing evidence for both conservation with and divergence from homologous complexes in other organisms.
Double-stranded DNA breaks and gene functions in recombination and meiosis
- BiologyCell Research
- 2006
It is shown that the failure to repair these meiotic DSBs results in abnormal chromosomal alternations, leading to disrupted meiosis, and the functions of RecA homologs have improved the understanding of the mechanisms underlying meiotic homologous recombination.
Noncanonical meiosis in the nematode Caenorhabditis elegans as a model for studying the molecular bases of the homologous chromosome synapsis, crossing over, and segregation
- BiologyRussian Journal of Genetics
- 2017
The study of meiosis in C. elegans allows for separate investigation of synapsis and recombination of homologous chromosomes and provides material for studying the evolution of meiotic pattern.
Meiotic Chromosome Synapsis in Yeast Can Occur Without Spo11-Induced DNA Double-Strand Breaks
- BiologyGenetics
- 2004
The results demonstrate that although the Spo11-induced DSBs obviously promote synapsis in yeast, the presence of Spo11 is not an absolute requirement forsynapsis.
A Component of C. elegans Meiotic Chromosome Axes at the Interface of Homolog Alignment, Synapsis, Nuclear Reorganization, and Recombination
- BiologyCurrent Biology
- 2004
Identification of DSB-1, a Protein Required for Initiation of Meiotic Recombination in Caenorhabditis elegans, Illuminates a Crossover Assurance Checkpoint
- BiologyPLoS genetics
- 2013
This work identifies a novel component of the DSB machinery in C. elegans, sheds light on an important pathway that regulates DSB formation for crossover assurance, and proposes a model for crossover assurances that acts through DSB-1 to maintain a D SB-permissive state until all chromosome pairs acquire crossover precursors.
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