Meiotic Crossover Control by Concerted Action of Rad51-Dmc1 in Homolog Template Bias and Robust Homeostatic Regulation

@inproceedings{Lao2013MeioticCC,
  title={Meiotic Crossover Control by Concerted Action of Rad51-Dmc1 in Homolog Template Bias and Robust Homeostatic Regulation},
  author={Jessica P. Lao and Veronica J Cloud and Chu-Chun Huang and Jennifer T Grubb and Drew Thacker and Chih-Ying Lee and Michael E. Dresser and Neil Hunter and Douglas K. Bishop},
  booktitle={PLoS genetics},
  year={2013}
}
During meiosis, repair of programmed DNA double-strand breaks (DSBs) by recombination promotes pairing of homologous chromosomes and their connection by crossovers. Two DNA strand-exchange proteins, Rad51 and Dmc1, are required for meiotic recombination in many organisms. Studies in budding yeast imply that Rad51 acts to regulate Dmc1's strand exchange activity, while its own exchange activity is inhibited. However, in a dmc1 mutant, elimination of inhibitory factor, Hed1, activates Rad51's… CONTINUE READING
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Hochwagen A (2011) Checkpoint mechanisms: the puppet masters of meiotic prophase

  • AJ MacQueen
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