Meiosis-activating sterol and the maturation of isolated mouse oocytes.

  title={Meiosis-activating sterol and the maturation of isolated mouse oocytes.},
  author={Stephen M Downs and Bing Ruan and George J. Schroepfer},
  journal={Biology of reproduction},
  volume={64 1},
This study was carried out to examine the effects of the meiosis-activating C(29) sterol, 4,4-dimethyl-5 alpha-cholesta-8,14, 24-trien-3 beta-ol (FF-MAS), on mouse oocyte maturation in vitro. Cumulus cell-enclosed oocytes (CEO) and denuded oocytes (DO) from hormonally primed, immature mice were cultured 17-18 h in minimum essential medium (MEM) containing 4 mM hypoxanthine plus increasing concentrations of FF-MAS. The sterol induced maturation in DO with an optimal concentration of 3 microg/ml… CONTINUE READING


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