Meier-Gorlin syndrome and Wolf-Hirschhorn syndrome: two developmental disorders highlighting the importance of efficient DNA replication for normal development and neurogenesis.

@article{Kerzendorfer2013MeierGorlinSA,
  title={Meier-Gorlin syndrome and Wolf-Hirschhorn syndrome: two developmental disorders highlighting the importance of efficient DNA replication for normal development and neurogenesis.},
  author={Claudia Kerzendorfer and Rita Colnaghi and Iga Abramowicz and Gillian Carpenter and Mark O'Driscoll},
  journal={DNA repair},
  year={2013},
  volume={12 8},
  pages={637-44}
}
Microcephaly represents one of the most obvious clinical manifestations of impaired neurogenesis. Defects in the DNA damage response, in DNA repair, and structural abnormalities in centrosomes, centrioles and the spindle microtubule network have all been demonstrated to cause microcephaly in humans. Work describing novel functional defects in cell lines from individuals with either Meier-Gorlin syndrome or Wolf-Hirschhorn syndrome highlight the significance of optimal DNA replication and S… CONTINUE READING