Mei-S332, a drosophila protein required for sister-chromatid cohesion, can localize to meiotic centromere regions

@article{Kerrebrock1995MeiS332AD,
  title={Mei-S332, a drosophila protein required for sister-chromatid cohesion, can localize to meiotic centromere regions},
  author={Anne W. Kerrebrock and Daniel P. Moore and Jim S. Wu and Terry L Orr-Weaver},
  journal={Cell},
  year={1995},
  volume={83},
  pages={247-256}
}
Mutations in the Drosophila mei-S332 gene cause premature separation of the sister chromatids in late anaphase of meiosis I. Therefore, the mei-S332 protein was postulated to hold the centromere regions of sister chromatids together until anaphase II. The mei-S332 gene encodes a novel 44 kDa protein. Mutations in mei-S332 that differentially affect function in males or females map to distinct domains of the protein. A fusion of mei-S332 to the green fluorescent protein (GFP) is fully functional… CONTINUE READING

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