Megf10 regulates the progression of the satellite cell myogenic program

  title={Megf10 regulates the progression of the satellite cell myogenic program},
  author={Chet E Holterman and Fabien Le Grand and Shihuan Kuang and Patrick Seale and Michael Rudnicki},
  journal={The Journal of Cell Biology},
  pages={911 - 922}
We identify here the multiple epidermal growth factor repeat transmembrane protein Megf10 as a quiescent satellite cell marker that is also expressed in skeletal myoblasts but not in differentiated myofibers. Retroviral expression of Megf10 in myoblasts results in enhanced proliferation and inhibited differentiation. Infected myoblasts that fail to differentiate undergo cell cycle arrest and can reenter the cell cycle upon serum restimulation. Moreover, experimental modulations of Megf10 alter… CONTINUE READING


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