Megestrol acetate for treatment of advanced carcinoma of the prostate

@article{Johnson1975MegestrolAF,
  title={Megestrol acetate for treatment of advanced carcinoma of the prostate},
  author={D. E. Johnson and K E Kaesler and Alberto G Ayala},
  journal={Journal of Surgical Oncology},
  year={1975},
  volume={7}
}
Thirteen men, ranging in age from 53 to 73 years and with previously untreated metastatic carcinoma of the prostate, received megestrol acetate (a synthetic progestin) in doses of 120 mg daily. A beneficial clinical response with a mean duration of 47 weeks was achieved in 12 patients (92%). When relapse developed in 8 patients, a secondary response was readily obtained by orchiectomy. The results suggest that a staged hormonal approach, using progestin therapy initially, may offer additional… 
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Megestrol acetate in relapsed carcinoma of prostate.
TLDR
It was concluded that megestrol acetate has a role as second-line hormonal therapy in the management of prostatic carcinoma.
Phase II study of megestrol acetate for metastatic carcinoma of the prostate.
TLDR
Megestrol acetate has only limited efficacy in patients previously treated for prostatic cancer by hormonal manipulation.
Treatment of stage D prostatic carcinoma with megestrol acetate
TLDR
Nine previously untreated patients with stage D prostatic carcinoma received megestrol acetate 40 mg orally three times daily, and three of five patients who had failed prior hormonal therapy remained objectively stable while receiving megestro acetate.
Medical castration using megestrol acetate and minidose estrogen.
Flutamide and other antiandrogens in the treatment of advanced prostatic carcinoma.
TLDR
Antiandrogens offer an alternative mode of therapy for previously untreated patients with advanced prostatic cancer but have produced no convincing benefits in hormonally refractory patients.
Combination of Anandron with orchiectomy in treatment of metastatic prostate cancer. Results of a double-blind study.
Treatment of advanced cancer of prostate with megestrol acetate.
5 The role of endocrine therapy in prostatic cancer
Megestrol acetate plus minidose diethylstilbestrol in the treatment of carcinoma of the prostate.
TLDR
Since megestrol acetate plus minidose DES is equivalent to DES in achieving treatment responses in patients with carcinoma of the prostate, it is a preferable treatment because of its improved side-effect profile.
Treatment of prostatic cancer. Newer forms of androgen deprivation.
TLDR
Encouraging the initiation of androgen deprivation for patients with regional or distant metastases will improve the patient's course and attempts to provide a more complete androgen blockade hold the hope of delaying or preventing relapse, which usually occurs with continued androgens deprivation.
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