Megestrol Acetate and Mirtazapine for the Treatment of Unplanned Weight Loss in the Elderly
@article{Fox2009MegestrolAA, title={Megestrol Acetate and Mirtazapine for the Treatment of Unplanned Weight Loss in the Elderly}, author={Caroloine Fox and Angela K Treadway and Amie Taggart Blaszczyk and Rebecca B. Sleeper}, journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy}, year={2009}, volume={29} }
A rising concern among clinicians is treatment of unplanned weight loss in the elderly, especially given the predicted growth of this population over the next few decades. [] Key Method In a comprehensive search of the MEDLINE and International Pharmaceutical Abstracts databases, we identified all published reports on the use of megestrol acetate or mirtazapine for the treatment of weight loss and on any adverse events associated with these drugs.
39 Citations
Megestrol acetate for treatment of anorexia-cachexia syndrome.
- Medicine, PsychologyThe Cochrane database of systematic reviews
- 2013
This review shows that MA improves appetite and is associated with slight weight gain in cancer, AIDS and in patients with other underlying pathology, and lack of benefit in the same patients when MA was compared to other drugs.
Orexigenic agents in geriatric clinical practice
- Medicine
- 2013
The focus of this article has been limited to reviewing the evidence for current orexigenic agents that are used to treat elderly individuals who are experiencing IWL, and maintaining a healthy weight is an essential element of well-being and decreased morbidity and mortality.
Appetite Stimulants in Long Term Care: A Literature Review
- Medicine
- 2009
Current research related to the use of appetite stimulants in long term care, including mirtazepine, oxandrolone, dronabinol, and megesterol acetate is identified, with mixed results.
Polypharmacy and nutritional status in elderly people
- MedicineCurrent opinion in clinical nutrition and metabolic care
- 2012
The role of polypharmacy on nutritional status among elderly people is unclear and some diseases promote malnutrition; thus, the independent role of drugs for nutritional status is challenging to determine.
Polypharmacy and Rational Prescribing: Changing the Culture of Medicine One Patient at a Time
- MedicineCurrent Physical Medicine and Rehabilitation Reports
- 2019
Physiatrists are well positioned to have a positive impact on rational prescribing and polypharmacy given their emphasis on function, familiarity with non-medication treatment modalities, and an embrace of a biopsychosocial orientation.
Older Adults With Unintended Weight Loss: The Role of Appetite Stimulants.
- MedicineHome healthcare now
- 2018
Understanding the dosage, side effects, and proper usage of appetite stimulants, such megestrol acetate, mirtazapine, and dronabinol, is crucial in order to provide safe and effective patient care.
Unintentional weight loss in older adults
- MedicineCanadian Medical Association Journal
- 2011
Treatment focuses on the underlying cause, and nutritional supplements and flavor enhancers, and dietary modification that takes into account patient preferences and chewing or swallowing disabilities may be considered.
Histamine-1 receptor antagonism for treatment
- Medicine, Psychology
- 2012
Over-the-counter antihistamines may have a role for short-term insomnia treatment in younger adults, but tolerance develops rapidly, and mirtazapine should not be used solely for the treatment of insomnia.
Assessment and Treatment of the Anorexia of Aging: A Systematic Review
- Medicine, PsychologyNutrients
- 2019
Appetite loss in older people, the ‘Anorexia of Aging’ (AA), is common, associated with under-nutrition, sarcopenia, and frailty and yet receives little attention, so standardized assessment is important for future research.
Histamine-1 receptor antagonism for treatment of insomnia.
- Medicine, PsychologyJournal of the American Pharmacists Association : JAPhA
- 2012
Over-the-counter antihistamines may have a role for short-term insomnia treatment in younger adults, but tolerance develops rapidly, and mirtazapine should not be used solely for the treatment of insomnia.
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