Megavitamin and Dietary Treatment in Schizophrenia: A Randomised, Controlled Trial

@article{Vaughan1999MegavitaminAD,
  title={Megavitamin and Dietary Treatment in Schizophrenia: A Randomised, Controlled Trial},
  author={Kevin Frederick Vaughan and Nathaniel Mcconaghy},
  journal={Australian and New Zealand Journal of Psychiatry},
  year={1999},
  volume={33},
  pages={84 - 88}
}
  • K. Vaughan, N. Mcconaghy
  • Published 1 February 1999
  • Medicine, Psychology
  • Australian and New Zealand Journal of Psychiatry
Objective: The aim of this study was to assess the efficacy of adjunctive megavitamin and dietary treatment in schizophrenia. Method: Arandom allocation double-blind, controlled comparison of dietary supplement and megavitamin treatment, and an alternative procedure was given for 5 months to 19 outpatients with a diagnosis of schizophrenia. In addition to usual follow-up, the experimental group received amounts of megavitamins based on their individual serum vitamin levels plus dietary… 
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References

SHOWING 1-10 OF 31 REFERENCES
Nicotinic acid therapy in chronic schizophrenia.
Nicotinic Acid in the Prevention and Treatment of Methionine-Induced Exacerbation of Psychopathology in Schizophrenics *
TLDR
Nicotinic acid failed to prevent by prior administration or to relieve by subsequent administration, the methionine-tranylcypromine-induced exacerbation of psychopathology, and the possibility of a toxic psychosis due to the metabolite, methamphetamineionine sulfoximine, must be seriously considered.
A search for responders to niacin supplementation.
TLDR
It is suggested that patients with dissociative psychosis and a history of interpersonal participation may respond well with high-dosage niacin as supplementary to other medication and treatment.
The effects of nicotinic acid, nicotinamide, and placebo on the chronic schizophrenic.
TLDR
Analysis of the results failed to show any evidence that the treatments were influencing the patients, and massive doses of nicotinic acid and nicotinamide were tested on the chronic schizophrenic together with an inert placebo.
Psychosocial functioning and subjective experience in schizophrenia.
TLDR
This study examines the relationship between psychosocial functioning and subjective experience in 193 individuals diagnosed with schizophrenia or schizoaffective disorder according to Research Diagnostic Criteria to suggest a primary and pervasive relationship between the disorder-related variables and subjective experienced and a secondary and less pronounced relationship between functional status variables and objective experience.
Orthomolecular Psychiatry
TLDR
Biochemical and genetic arguments support the idea that orthomolecular therapy, the provision for the individual person of the optimum concentrations of important normal constituents of the brain, may be the preferred treatment for many mentally ill patients.
Letter to the editor
Diagnosis of allergy by an in-vitro test for allergen antibodies.
Potentiation of Therapeutic Effects of Nicotinic Acid by Pyridoxine in Chronic Schizophrenics *
TLDR
On a signale qu'il peut se produire chez les patients schizophreniques un blocage de l'intervention de the kynurenine conduisant a une formation excessive d'indoles and a une deficience d'acide nicotinique.
“Mental health literacy”: a survey of the public's ability to recognise mental disorders and their beliefs about the effectiveness of treatment
Objectives: To assess the public's recognition of mental disorders and their beliefs about the effectiveness of various treatments (“mental health literacy”).
...
...