Megalomycin C, a macrolide antibiotic that blocks protein glycosylation and shows antiviral activity

@article{Alarcn1988MegalomycinCA,
  title={Megalomycin C, a macrolide antibiotic that blocks protein glycosylation and shows antiviral activity},
  author={Balbino Alarc{\'o}n and Mar{\'i}a Eugenia Gonz{\'a}lez and Luis Carrasco},
  journal={FEBS Letters},
  year={1988},
  volume={231}
}
Megalomycin C, a natural macrolide antibiotic showed a potent antiherpetic activity. At concentrations that efficiently prevented HSV‐1 multiplication, the compound had no cytotoxic or antiproliferative effects. Viral DNA and protein synthesis took place at normal levels in the presence of the antibiotic, suggesting that neither the translation of viral mRNA, nor the synthesis of viral nucleic acids was affected. The incorporation of mannose and galactosamine into viral proteins was blocked and… Expand
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