Megalin functions as an endocytic sonic hedgehog receptor.

@article{McCarthy2002MegalinFA,
  title={Megalin functions as an endocytic sonic hedgehog receptor.},
  author={Robert A McCarthy and Jeremy L. Barth and Mastan Rao Chintalapudi and Christian Knaak and W. Scott Argraves},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 28},
  pages={
          25660-7
        }
}
Embryos deficient in the morphogen Sonic hedgehog (Shh) or the endocytic receptor megalin exhibit common neurodevelopmental abnormalities. Therefore, we have investigated the possibility that a functional relationship exists between the two proteins. During embryonic development, megalin was found to be expressed along the apical surfaces of neuroepithelial cells and was coexpressed with Shh in the ventral floor plate of the neural tube. Using enzyme-linked immunosorbent assay, homologous… CONTINUE READING
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