Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule.

@article{Christensen2001MegalinAC,
  title={Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule.},
  author={Erik Ils\o Christensen and Henrik Birn},
  journal={American journal of physiology. Renal physiology},
  year={2001},
  volume={280 4},
  pages={F562-73}
}
The multiligand, endocytic receptors megalin and cubilin are colocalized in the renal proximal tubule. They are heavily expressed in the apical endocytic apparatus. Megalin is a 600-kDa transmembrane protein belonging to the low-density lipoprotein-receptor family. The cytoplasmic tail contains three NPXY motifs that mediate the clustering in coated pits and are possibly involved in signaling functions. Cubilin, also known as the intestinal intrinsic factor-cobalamin receptor, is a 460-kDa… CONTINUE READING
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