Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins.

@article{Hammad2000MegalinAI,
  title={Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins.},
  author={Samar M Hammad and Jeremy L. Barth and Christian Knaak and W. Scott Argraves},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 16},
  pages={12003-8}
}
Cubilin has recently been shown to function as an endocytic receptor for high density lipoproteins (HDL). The lack of apparent transmembrane and cytoplasmic domains in cubilin raises questions as to the means by which it can mediate endocytosis. Since cubilin has been reported to bind the endocytic receptor megalin, we explored the possibility that megalin acts in conjunction with cubilin to mediate HDL endocytosis. While megalin did not bind to HDL, delipidated HDL, or apoA-I, it was found to… CONTINUE READING
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3604–3606 Megalin and Cubilin Are HDL Co-receptors

  • J. C. Fyfe, U. Giger, +4 authors D. F. Patterson
  • J. Biol
  • 1991

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