Megalin-Mediated Specific Uptake of Chitosan/siRNA Nanoparticles in Mouse Kidney Proximal Tubule Epithelial Cells Enables AQP1 Gene Silencing

@inproceedings{Gao2014MegalinMediatedSU,
  title={Megalin-Mediated Specific Uptake of Chitosan/siRNA Nanoparticles in Mouse Kidney Proximal Tubule Epithelial Cells Enables AQP1 Gene Silencing},
  author={Shan Gao and San Hein and Frederik Dagn{\ae}s-Hansen and Kathrin Weyer and Chuanxu Yang and Rikke Beck Nielsen and Erik Ils\o Christensen and Robert Andrew Fenton and J\orgen Kjems},
  booktitle={Theranostics},
  year={2014}
}
RNAi-based strategies provide a great therapeutic potential for treatment of various human diseases including kidney disorders, but face the challenge of in vivo delivery and specific targeting. The chitosan delivery system has previously been shown to target siRNA specifically to the kidneys in mice when administered intravenously. Here we confirm by 2D and 3D bioimaging that chitosan formulated siRNA is retained in the kidney for more than 48 hours where it accumulates in proximal tubule… CONTINUE READING

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