Megakaryocytopoiesis and thrombopoiesis in hematopoietic stem cells exposed to ionizing radiation.

@article{Monzen2011MegakaryocytopoiesisAT,
  title={Megakaryocytopoiesis and thrombopoiesis in hematopoietic stem cells exposed to ionizing radiation.},
  author={Satoru Monzen and Emiko Tashiro and Ikuo Kashiwakura},
  journal={Radiation research},
  year={2011},
  volume={176 6},
  pages={
          716-24
        }
}
Hematopoietic processes, especially megakaryocytopoiesis and thrombopoiesis, are highly sensitive to extracellular oxidative stresses such as ionizing radiation and chemotherapeutic agents. This study examined the terminal maturation of megakaryocytes and platelet production in hematopoietic stem/progenitor cells (HSPCs) exposed to ionizing radiation. Highly purified CD34(+) cells derived from human placental/umbilical cord blood were exposed to X rays (2 Gy, 150 kVp, 20 mA; 0.5-mm aluminum and… CONTINUE READING
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