Megakaryocytopoiesis and platelet production: does stem cell factor play a role?

Megakaryocytopoiesis, resulting in the production and release of platelets, is a multistage procession of cellular differentiation and maturation which is regulated by a constellation of cytokines. Since thrombocytopenia is a frequent dose-limiting toxicity of chemotherapy, newly-identified cytokines have been actively investigated for their potential… CONTINUE READING