Megakaryocytes, malignancy and bone marrow vascular niches.

  title={Megakaryocytes, malignancy and bone marrow vascular niches.},
  author={Bethan Psaila and David Lyden and Irene A. G. Roberts},
  journal={Journal of thrombosis and haemostasis : JTH},
  volume={10 2},
Dynamic interactions between hematopoietic cells and their specialized bone marrow microenvironments, namely the vascular and osteoblastic 'niches', regulate hematopoiesis. The vascular niche is conducive for thrombopoiesis and megakaryocytes may, in turn, regulate the vascular niche, especially in supporting vascular and hematopoietic regeneration following irradiation or chemotherapy. A role for platelets in tumor growth and metastasis is well established and, more recently, the vascular… CONTINUE READING
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