Megakaryocyte development and platelet production

@article{Deutsch2006MegakaryocyteDA,
  title={Megakaryocyte development and platelet production},
  author={Varda R. Deutsch and Aaron Tomer},
  journal={British Journal of Haematology},
  year={2006},
  volume={134}
}
Megakaryocytopoiesis involves the commitment of haematopoietic stem cells, and the proliferation, maturation and terminal differentiation of the megakaryocytic progenitors. Circulating levels of thrombopoietin (TPO), the primary growth‐factor for the megakaryocyte (MK) lineage, induce concentration–dependent proliferation and maturation of MK progenitors by binding to the c‐Mpl receptor and signalling induction. Decreased platelet turnover rates results in increased concentration of free TPO… 

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The regulation of megakaryocytopoiesis and platelet production in normal and disease states, and the innovative drugs and therapeutic modalities to stimulate or decrease thrombopoiedis are reviewed.

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    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2010
It is reported that sphin‐gosine 1‐phosphate receptor 4 (S1P4) is specifically up‐regulated during the development of human megakaryo‐cytes from progenitor cells and is expressed in mature murine megakARYocytes.

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The interaction and role of BM niches in orchestrating megakaryopoiesis in ITP patients is examined and how these factors can be exploited to improve the quality of patient treatment and prognosis is discussed.

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Key aspects of MK physiology and structure are discussed and the molecular pathways governing these fascinating cells under normal and some pathological conditions are explored.

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This study has mapped parallels between the MKP states in vivo and in vitro and allowed the purification of MKPs, accelerating the progress of in vitro-derived transfusion products towards the clinic.

TPO-independent megakaryocytopoiesis.

OP9 Bone Marrow Stroma Cells Differentiate into Megakaryocytes and Platelets

It is revealed that mouse bone marrow stroma cell line OP9 cells differentiated into MKs and platelets in vitro, providing the first evidence for the differentiation of OP8 cells into MK's and platelet generation.

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The understanding of committed megakaryocytes and platelet release in vivo and in vitro, and how this knowledge can guide the development of in vitro-derived platelets for clinical application are focused on.
...

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