Megakaryoblastic transformation in myeloproliferative disorders.

@article{Jacobs1984MegakaryoblasticTI,
  title={Megakaryoblastic transformation in myeloproliferative disorders.},
  author={Peter Jacobs and Isabelle Le Roux and Lawrence Jacobs},
  journal={Cancer},
  year={1984},
  volume={54 2},
  pages={297-302}
}
Megakaryoblastic transformation, with cells showing characteristic morphology and ultrastructural cytochemistry, developed in two patients with agnogenic myeloid metaplasia or myelofibrosis, and in one with chronic granulocytic leukemia. From the onset of the leukemic phase, all three have followed a relatively benign clinical course, surviving for 48, 29, and 24 months, respectively; only hydroxyurea has been necessary to control thrombocytosis. This experience emphasizes that it is possible… CONTINUE READING