Mefloquine selectively increases asynchronous acetylcholine release from motor nerve terminals

@article{Mcardle2006MefloquineSI,
  title={Mefloquine selectively increases asynchronous acetylcholine release from motor nerve terminals},
  author={J J Mcardle and Lawrence C. Sellin and Kathleen M. Coakley and Joseph G. Potian and Kormakur Hognason},
  journal={Neuropharmacology},
  year={2006},
  volume={50},
  pages={345-353}
}
Effectiveness against chloroquine-resistant Plasmodia makes mefloquine a widely used antimalarial drug. However, mefloquine's neurologic effects offset this therapeutic advantage. Cellular actions which might contribute to the neurologic effects of mefloquine are not understood. Structural similarity to tacrine suggested that mefloquine might alter cholinergic synaptic transmission. Therefore, we examined mefloquine's effects at a model cholinergic synapse. Triangularis sterni nerve-muscle… CONTINUE READING
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