Mefloquine inhibits cholinesterases at the mouse neuromuscular junction

@article{Mcardle2005MefloquineIC,
  title={Mefloquine inhibits cholinesterases at the mouse neuromuscular junction},
  author={J J Mcardle and Lawrence C. Sellin and Kathleen M. Coakley and Joseph G. Potian and Kormakur Hognason},
  journal={Neuropharmacology},
  year={2005},
  volume={49},
  pages={1132-1139}
}
Mefloquine is effective against drug-resistant Plasmodium falciparum. This property, along with its unique pharmacokinetic profile, makes mefloquine a widely prescribed antimalarial drug. However, mefloquine has neurologic effects which offset its therapeutic advantages. Cellular actions underlying mefloquine's neurologic effects are poorly understood. Here, we demonstrate that mefloquine inhibits human recombinant acetylcholinesterase. To explore the consequences of this action, we… CONTINUE READING
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