Mefloquine inhibits cholinesterases at the mouse neuromuscular junction

@article{McArdle2005MefloquineIC,
  title={Mefloquine inhibits cholinesterases at the mouse neuromuscular junction},
  author={Joseph J. McArdle and Lawrence C. Sellin and Kathleen M. Coakley and Joseph G. Potian and Mary C. Quinones-Lopez and Clint A Rosenfeld and Lester G. Sultatos and Kormakur Hognason},
  journal={Neuropharmacology},
  year={2005},
  volume={49},
  pages={1132-1139}
}

Mefloquine enhances nigral gamma-aminobutyric acid release via inhibition of cholinesterase.

Data suggest that mefloquine enhances GABA release through its inhibition of cholinesterase, which allows accumulation of endogenously released acetylcholine, which activates neuronal nicotinic receptors on GABAergic nerve terminals.

Mefloquine Enhances Nigral γ-Aminobutyric Acid Release via Inhibition of Cholinesterase

Data suggest that mefloquine enhances GABA release through its inhibition of cholinesterase, which allows accumulation of endogenously released acetylcholine, which activates neuronal nicotinic receptors on GABAergic nerve terminals.

Review of the mechanism underlying mefloquine-induced neurotoxicity

The aim of this study was to review the literature on the neurotoxic mechanisms of action of mefloquine to better understand its potential toxicity in the central nervous system, highlighting the mechanisms that lead to its psychiatric disorders.

Antagonistic postsynaptic and presynaptic actions of cyclohexanol on neuromuscular synaptic transmission and function

The results explain the pattern of neuromuscular dysfunction following ingestion of organophosphorus insecticides containing cyclo hexanol precursors and suggest that cyclohexanol may facilitate investigation of mechanisms regulating synaptic strength at NMJs.

Cellular targets of mefloquine.

Acetylcholine Release in Mouse Motor Synapses. Changes of Purinergic Regulation under Conditions of Pharmacological Blockade of Pannexin 1 and Its Genetic Knockout

It was concluded that the lack of expression of the pannexin 1 gene caused by its knockout and acute blockade of pan Nexin 1 equally affected the secretion of ACh due to a decrease in the concentration of purines in the synaptic cleft.

Adverse neuropsychiatric effects of antimalarial drugs

A more systematic approach to assess the neuropsychiatric adverse effects of new or repurposed antimalarial drugs on their safety, tolerability and efficacy phases of clinical studies and in post-marketing surveillance, is needed to ensure that these life-saving tools remain available and can be prescribed with appropriate caution and medical judgment.

Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis

Efficacy of THN201, a Combination of Donepezil and Mefloquine, to Reverse Neurocognitive Deficits in Alzheimer’s Disease

It was demonstrated that the Cx modulator mefloquine (MEF) significantly enhanced the procognitive effect of DPZ in both models and local genetic silencing of astrocyte Cxs in the hippocampus was found to enhance the proc cognitive effect ofDPZ, pointing out the importance of Cx-dependent astroCyte networks in memory processes.

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