Mefloquine in the treatment of progressive multifocal leukoencephalopathy.

  title={Mefloquine in the treatment of progressive multifocal leukoencephalopathy.},
  author={Teneille Emma Gofton and Amal Al-Khotani and Brett O'Farrell and Lee Cyn Ang and R S Mclachlan},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  volume={82 4},
Mefloquine, an antimalarial medication with efficacy against JC virus, was used to treat progressive multifocal leukoencephalopathy. A 54-year-old woman with sarcoidosis presented with a progressive cerebellar syndrome. MRI showed lesions affecting the right cerebellum that progressed over time to the brainstem. JC virus was found in the cerebrospinal fluid (CSF), and brain biopsy confirmed the diagnosis of progressive multifocal leukoencephalopathy. Mefloquine 1000 mg/week was initiated 6… CONTINUE READING