Mefloquine in the treatment of progressive multifocal leukoencephalopathy

@article{Gofton2010MefloquineIT,
  title={Mefloquine in the treatment of progressive multifocal leukoencephalopathy},
  author={Teneille E. Gofton and A Al-Khotani and B. O'Farrell and Lee Cyn Ang and Richard S. McLachlan},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  year={2010},
  volume={82},
  pages={452 - 455}
}
Mefloquine, an antimalarial medication with efficacy against JC virus, was used to treat progressive multifocal leukoencephalopathy. A 54-year-old woman with sarcoidosis presented with a progressive cerebellar syndrome. MRI showed lesions affecting the right cerebellum that progressed over time to the brainstem. JC virus was found in the cerebrospinal fluid (CSF), and brain biopsy confirmed the diagnosis of progressive multifocal leukoencephalopathy. Mefloquine 1000 mg/week was initiated 6… 

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