Mefloquine in the nucleus accumbens promotes social avoidance and anxiety-like behavior in mice.

@article{Heshmati2016MefloquineIT,
  title={Mefloquine in the nucleus accumbens promotes social avoidance and anxiety-like behavior in mice.},
  author={M. G. Sahab A. A. R. Heshmati and Sam A Golden and Madeline L. Pfau and Daniel J Christoffel and Elena L Seeley and Michael E Cahill and Lena A. Khibnik and Scott J Russo},
  journal={Neuropharmacology},
  year={2016},
  volume={101},
  pages={351-7}
}
Mefloquine continues to be a key drug used for malaria chemoprophylaxis and treatment, despite reports of adverse events like depression and anxiety. It is unknown how mefloquine acts within the central nervous system to cause depression and anxiety or why some individuals are more vulnerable. We show that intraperitoneal injection of mefloquine in mice, when coupled to subthreshold social defeat stress, is sufficient to produce depression-like social avoidance behavior. Direct infusion of… CONTINUE READING
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Epigenetic regulation of RAC1 induces synaptic remodeling in stress

  • S. A. Golden, D. J. Christoffel, M. Heshmati, G. E. Hodes, J. Magida, K Davis
  • 2013
Highly Influential
5 Excerpts

Epigenetic regulation of RAC 1 induces synaptic remodeling in stress disorders and depression

  • S. A. Golden, D. J. Christoffel, M. Heshmati, G. E. Hodes, J. Magida, K. Davis
  • Nat . Med .
  • 2013
3 Excerpts

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