Mefloquine Enhances Nigral γ-Aminobutyric Acid Release via Inhibition of Cholinesterase

@article{Zhou2006MefloquineEN,
  title={Mefloquine Enhances Nigral $\gamma$-Aminobutyric Acid Release via Inhibition of Cholinesterase},
  author={Chunyi Zhou and Cheng Xiao and Joseph J. McArdle and Jiang Hong Ye},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2006},
  volume={317},
  pages={1155 - 1160}
}
  • Chunyi ZhouCheng Xiao J. Ye
  • Published 1 June 2006
  • Biology, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
Mefloquine, a widely used antimalarial drug, has many neuropsychiatric effects. Although the mechanisms underlying these side effects remain unclear, recent studies show that mefloquine enhances spontaneous transmitter release and inhibits cholinesterases. In this study, we examined the effect of mefloquine on GABA receptor-mediated, spontaneous inhibitory postsynaptic currents (sIPSCs) of dopaminergic neurons, mechanically dissociated from the substantia nigra pars compacta of rats aged 6 to… 

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