Mefenamic acid — A nonsteroid antiinflammatory agent

  title={Mefenamic acid — A nonsteroid antiinflammatory agent},
  author={F. P. Trinus and N. A. Mokhort and L. M. Yagupol’skii and A. G. Fadeicheva and V. S. Danilenko and T. K. Ryabukha and Yu. A. Fialkov and L. M. Kirichek and {\'E}. S. Endel'man and G. A. Get'man},
  journal={Pharmaceutical Chemistry Journal},
The inflammatory process is, as known, a pathological symptom of many illnesses. Therefore, the regulation of the inflammatory reaction, including that by means of pharmacological compounds, is one of the important problems of modern medicine. In particular, medicinal compounds are used in clinics, which inhibit the development of the inflammatory process. The suppression of inflammation makes it possible to shorten the time of the illness and to decrease the gravity of the disease and its… 
The Role of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in the Treatment of Patients With Hepatic Disease: A Review Article
Due to the potential adverse effects of NSAIDs in patients with hepatic disease, their impact on all bodily systems should be emphasized when determining whether their use is necessary.
Zebrafish based strategy for the identification of a potential pharmacophore for apoptosis: a greener CuAAC approach for novel 1,2,3-triazoles derived from mefenamic acid
A series of triazole substituted mefenamic acid derivatives were designed and synthesized via a CuAAC under green conditions and showed encouraging apoptotic properties and safety profiles and seemed to have medicinal value in zebrafish embryos.
Intermolecular Reductive C-N Cross Coupling of Nitroarenes and Boronic Acids by PIII/PV═O Catalysis.
A main group-catalyzed method for the synthesis of aryl- and heteroarylamines by intermolecular C-N coupling is reported, which constitutes a new route from readily available building blocks to valuable nitrogen-containing products with complementarity in both scope and chemoselectivity to existing catalytic C- N coupling methods.
Efficiency of membrane technology, activated charcoal, and a micelle-clay complex for removal of the acidic pharmaceutical mefenamic acid
  • Samer Khalaf, F. Al-Rimawi, R. Karaman
  • Engineering
    Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering
  • 2013
The combined results demonstrated that an integration of a micelle-clay column in the plant system has a good potential to improve the removal efficiency of the plant towards NSAID drugs such as mefenamic acid.
Aminocyanation by the addition of N-CN bonds to arynes: chemoselective synthesis of 1,2-bifunctional aminobenzonitriles.
An efficient aminocyanation by the direct addition of aryl cyanamides to arynes is described, enabling incorporation of highly useful amino and cyano groups synchronously via cleavage of inert N-CN
Palladium-catalyzed mono-N-allylation of unprotected anthranilic acids with allylic alcohols in aqueous media.
Palladium-catalyzed N-allylation of anthranilic acids 1a-j with allyl alcohol 2a in the presence of Pd(OAc)(2), sodium diphenylphosphinobenzene-3-sulfonate (TPPMS) in THF-H(2)O at room temperature


Nonsteroid anti-inflammatory agents.
  • C. Winter
  • Medicine
    Annual review of pharmacology
  • 1966
The treatment of rheumatic diseases by anti-inflammatory drugs is a re­ cent development, except for the use of salicylates, and interest in this field has increased at an accelerating pace during the 1960's.
The pharmacology of slow reacting substance C and of arachidonic acid
In vivo and in vitro AA or SRS-C induced release of PG-like mediators, as well as AA induced platelet aggregation, are also blocked by SH agents, the most effective and specific being thioglycerol and sodium diethyldithio-carbamate.
Experiments in relief of clinical pain with N-(2,3-xylyl)-anthranilic acid (CI-473; mefenamic acid).
In double blind experiments of randomized cross-over design, on patients of miscellaneous diagnoses suffering chronic pain, relief was scored thrice daily for 6 days of each treatment, 1½ hours after oral medication, and prodilidine was again found to be less than half as potent as codeine, mg for mg.
Optical Studies of Drug-Protein Complexes
Spectral changes which accompanied the binding of flufenamic acid to human serum albumin strongly suggested that the aromatic portion of the drug was inserted into a hydrophobic crevice in the protein, while the carboxylate group of theDrug interacted with a cationic site on the protein surface.
Anti-inflammatory, antipyretic and antinociceptive properties of N-(2,3-xylyl)anthranilic acid (mefenamic acid).
N-(2,3-xylyl)anthranilic acid (CI-473; mefenamic acid) is an anti-inflammatory agent with an acute potency 0.95%, without adrenal dependence or significant corticoid hormonal effects, and antagonizes yeast pyresis in rats with about the same acute oral potency as phenylbutazone.