Meeting report: Proteases, extracellular matrix, and cancer: an AACR Special Conference in Cancer Research.

@article{Wall2003MeetingRP,
  title={Meeting report: Proteases, extracellular matrix, and cancer: an AACR Special Conference in Cancer Research.},
  author={Steven J Wall and Yong Jiang and Ruth J. Muschel and Yves A DeClerck},
  journal={Cancer research},
  year={2003},
  volume={63 15},
  pages={4750-5}
}
Our view of the ECM and its role in cancer has substantially evolved over the last decade. It is now apparent that the ECM is much more than a physical barrier against tumor invasion. It is an integral part of the tumor microenvironment and extensively modified by proteases during malignant progression. We have begun to appreciate that these proteases do more than just degrade the ECM and allow cells to invade and metastasize. Their role in earlier stages of malignant transformation and… CONTINUE READING