Medulloblastoma comprises four distinct molecular variants.

@article{Northcott2011MedulloblastomaCF,
  title={Medulloblastoma comprises four distinct molecular variants.},
  author={Paul A. Northcott and Andrey Korshunov and Hendrik Witt and Thomas Hielscher and Charles G. Eberhart and Stephen Mack and Eric Bouffet and Steven C. Clifford and Cynthia E. Hawkins and Pim French and James T. Rutka and Stefan Pfister and Michael D. Taylor},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 11},
  pages={1408-14}
}
PURPOSE Recent genomic approaches have suggested the existence of multiple distinct subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine how many subgroups of the disease exist, how they differ, and the extent of overlap between subgroups. METHODS We determined gene expression profiles and DNA copy number aberrations for 103 primary medulloblastomas. Bioinformatic tools were used for class discovery of medulloblastoma subgroups based on the most informative… CONTINUE READING
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