Medulloblastoma comprises four distinct molecular variants.

  title={Medulloblastoma comprises four distinct molecular variants.},
  author={Paul A. Northcott and Andrey Korshunov and Hendrik Witt and Thomas Hielscher and Charles G. Eberhart and Stephen Mack and Eric Bouffet and Steven C. Clifford and Cynthia E. Hawkins and Pim French and James T. Rutka and Stefan Pfister and Michael D. Taylor},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={29 11},
PURPOSE Recent genomic approaches have suggested the existence of multiple distinct subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine how many subgroups of the disease exist, how they differ, and the extent of overlap between subgroups. METHODS We determined gene expression profiles and DNA copy number aberrations for 103 primary medulloblastomas. Bioinformatic tools were used for class discovery of medulloblastoma subgroups based on the most informative… CONTINUE READING
Highly Influential
This paper has highly influenced 41 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 461 extracted citations

Clustering of self-organizing map identifies five distinct medulloblastoma subgroups.

Cancer biomarkers : section A of Disease markers • 2016
View 5 Excerpts
Highly Influenced

Mir-449a, a potential diagnostic biomarker for WNT group of medulloblastoma

Journal of Neuro-Oncology • 2016
View 15 Excerpts
Highly Influenced

Animal Models of Brain Tumors

View 20 Excerpts
Highly Influenced

Chemotherapy of Medulloblastoma in Children

Dezs, Schuler
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 34 references

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma.

Proceedings of the National Academy of Sciences of the United States of America • 2007

Similar Papers

Loading similar papers…