• DOI:10.1038/ncponc0794
Corpus ID: 24461280

Medulloblastoma: tumorigenesis, current clinical paradigm, and efforts to improve risk stratification

@article{Polkinghorn2007MedulloblastomaTC,
  title={Medulloblastoma: tumorigenesis, current clinical paradigm, and efforts to improve risk stratification},
  author={W. Polkinghorn and N. Tarbell},
  journal={Nature Clinical Practice Oncology},
  year={2007},
  volume={4},
  pages={295-304}
}

W. Polkinghorn, N. Tarbell

Published 2007

Medicine

Nature Clinical Practice Oncology

Medulloblastoma is the most common brain malignancy in children and tremendous advances have recently been made in understanding the pathogenesis of this tumor. The Hedgehog and Wingless signaling pathways are implicated in medulloblastoma development, and both pathways were discovered as a result of analyses of genetic syndromes associated with the tumor. Over the past 80 years, considerable progress has been made in the treatment of what was once a fatal disease. The first survival reports… CONTINUE READING

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